Gut-Brain Axis

 gut brain axis

What is the Gut-Brain Axis?

The gut-brain axis is the two-way communication system between your digestive system and your brain. They send messages through nerves, hormones, the immune system and the trillions of microbes that live in the gut. This link helps control mood, stress, digestion and even sleep [1][2].

What does the gut-brain axis actually do?

Think of your gut and brain as close teammates. They talk all day to keep your body in balance.

How the messages travel between your brain and gut Description
Nerves The vagus nerve is like a phone line between gut and brain, carrying fast signals both ways.
Hormones and chemicals The gut makes and reacts to messenger chemicals such as serotonin, which can influence mood and gut movement.
Immune system Immune cells in the gut send alerts that can change how the brain and gut behave.
Gut microbes Helpful bacteria and other microbes produce substances that can affect stress, appetite and inflammation.

Why the gut-brain axis matters

  • Digestion: Stress and emotions can change gut motility and sensitivity, which may affect bloating or bowel habits.
  • Mood and focus: Gut signals can influence how calm, alert or irritable you feel.
  • Sleep and energy: Gut hormones and microbes can nudge your sleep-wake rhythm and energy levels.
  • Immunity: A healthy gut helps train the immune system to respond appropriately.

What are the symptoms of gut-brain issues?

    • Feeling tense or low when your digestion is off [3]
    • Frequent tummy discomfort when stressed and irregular bowel habits without a clear cause [4]
    • Poor sleep alongside digestive upsets [5]

Important: Ongoing pain, weight loss, blood in stool, persistent vomiting, fever or symptoms that wake you at night need medical advice. Speak to your GP or an appropriate healthcare professional.

Everyday ways to support a healthy gut-brain axis

Food and drink

  • Eat plants often: Aim for a variety of fruit, veg, whole grains, nuts, seeds and pulses to feed helpful gut microbes.
  • Include fermented foods: Options like live yoghurt, kefir, sauerkraut or kimchi can add beneficial microbes.
  • Steady meals and fibre: Regular meals and gradual increases in fibre support comfortable digestion.
  • Hydration: Water helps fibre do its job and keeps things moving.

Mind and body habits

FAQs

Is it all in my head?

No. The gut has its own nerve network and chemical signals that influence real physical symptoms. The brain and gut affect each other in both directions.

Do I need a probiotic supplement?

Not always. Many people do well with a varied, plant-rich diet and fermented foods. Some probiotics may help in specific cases. If you are considering a supplement, ask a healthcare professional for personalised guidance.

Can stress really upset my stomach?

Yes. Stress can change gut movement and sensitivity, which may lead to cramps, urgency or bloating in some people.

Medical Disclaimer

This overview is educational and not a diagnosis. If you have ongoing symptoms, new symptoms or worrying signs, seek medical advice. A registered dietitian can help you build a simple plan that suits your lifestyle and medical needs.

Related terms

  • Microbiome
  • Vagus nerve
  • Serotonin
  • Fermented foods
  • Mindfulness

Nutritionist's Corner: Final Thoughts

“The gut and brain are partners. Small daily habits make a big difference: eat a variety of plants, include a little fermented food, drink enough water, move your body and practise short, regular stress-relief. If symptoms persist or worry you, get tailored advice from a registered professional.”
— Yusra Serdaroglu Aydin, MSc RD

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Sources

[1] Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015 Apr-Jun;28(2):203-209. PMID: 25830558; PMCID: PMC4367209.

[2] Lin Z, Jiang T, Chen M, Ji X, Wang Y. Gut microbiota and sleep: Interaction mechanisms and therapeutic prospects. Open Life Sci. 2024 Jul 18;19(1):20220910. doi: 10.1515/biol-2022-0910. PMID: 39035457; PMCID: PMC11260001.

[3] The gut-brain connection - Harvard Health Publishing

[4] Kraimi N, Ross T, Pujo J, De Palma G. The gut microbiome in disorders of gut-brain interaction. Gut Microbes. 2024 Jan-Dec;16(1):2360233. doi: 10.1080/19490976.2024.2360233. Epub 2024 Jul 1. PMID: 38949979; PMCID: PMC11218806.

[5] Kraimi N, Ross T, Pujo J, De Palma G. The gut microbiome in disorders of gut-brain interaction. Gut Microbes. 2024 Jan-Dec;16(1):2360233. doi: 10.1080/19490976.2024.2360233. Epub 2024 Jul 1. PMID: 38949979; PMCID: PMC11218806.

Author
Yusra Serdaroglu Aydin - Head of Nutrition & Registered Dietitian at Vivere

Yusra Serdaroglu Aydin, MSc RD

Head of Nutrition and Registered Dietitian

Yusra is a registered dietitian with a multidisciplinary background in nutrition, food engineering, and culinary arts. During her education, her curio...