How Does Sugar Affect the Gut?

Diet

11 April 2025

Sugar on a surface being collected on a wooden spoon

Most of us are aware that maintaining a balanced diet is essential for our overall health, but how often do you consider the impact of sugar on our gut? While sugar is a common part of our daily diet, its effects on the gut are not generally considered. Rather, we will think about how it affects our teeth and hyperactivity. In this article, we will explore what sugar is and how it affects your gut microbiota. We'll examine how excess sugar consumption impacts your gut health, consider if you should cut sugar entirely from your diet, and address other frequently asked questions about the relationship between sugar and the gut.

Key Takeaways

Here are the 5 biggest takeaways from this article about sugar and its effects on your gut:

  • Sucrose, the chemical name for sugar, is a simple carbohydrate found naturally in all plants, including fruits, vegetables, and nuts.

  • Consuming sugar can alter the composition and functionality of the gut microbiota, which are crucial for maintaining the intestinal barrier. 

  • Excessive sugar intake can disrupt the intestinal barrier, increase gut permeability, and lead to a condition known as dysbiosis, where non-beneficial bacteria outnumber beneficial ones.

  • High sugar consumption can lead to metabolic endotoxemia, causing chronic low-grade inflammation and metabolic dysregulation, such as insulin resistance and obesity.

  • Cutting out sugar completely is not necessary. Sugar is essential for brain function and is naturally present in many foods. However, moderation is key, as excessive sugar intake can disrupt gut bacteria.

What is sugar?

You may have heard the term "sucrose" before, but what does it actually mean and how does it relate to sugar? Sucrose is simply the chemical name for sugar, a type of simple carbohydrate found naturally in all plants including fruits, vegetables and nuts [1]. It is the sweet substance we commonly use to add flavour to our foods and drinks and is a common staple of the everyday diet.

Can consuming sugar affect your gut microbiota?

Consuming sugar can impact your gut microbiota. This is the community of microorganisms living in your digestive tract. Sugar can alter both the composition and the functionality of these microbes. When the balance of your gut microbiota is disturbed, it can weaken the intestinal barrier, which is crucial for keeping harmful substances out of your bloodstream. As a result, your immune system's efficiency may decline, making you more susceptible to illnesses. An imbalanced gut microbiota can hinder your body's ability to absorb essential nutrients from food, potentially leading to deficiencies [2]. It should be noted however that low levels of sugar will not alter your gut microbiota to such an extent.

How does excessive consumption of sugar affect the gut?

Excessive consumption of sugar can have several negative effects on the gut. A recent study found that high sugar intake leads to a loss of important immune cells in mice. Sugar appears to disrupt the balance of the microbiome, favouring non-beneficial bacteria over those that support immune health. The study also highlights a strong connection between the loss of these immune cells and the development of certain diseases, such as diabetes [3].

Both high blood sugar levels (hyperglycemia) and excessive sugar intake can disrupt the intestinal barrier, increasing gut permeability. This condition, often referred to as a leaky gut, allows harmful substances to pass more easily into the bloodstream, leading to inflammation and other health issues. Excessive sugar intake can also cause significant imbalances in the gut microbiota, known as dysbiosis [4].

What are the implications of high dietary sugars?

High dietary sugar intake can have several serious implications on your health. By altering the gut microbiota, excessive sugar consumption can promote metabolic endotoxemia, a condition where endotoxins enter the bloodstream, leading to low-grade inflammation. This chronic inflammation can contribute to the development of metabolic dysregulation, such as insulin resistance and obesity. The excess energy provided by high sugar intake can also make these issues worse, leading to a range of health problems other than just weight gain [5].

Should I cut out sugar completely?

Cutting out sugar completely is not necessary and may not be beneficial. Sugar is primarily absorbed in the small intestine, and the majority of gut microbes reside in the large intestine. Therefore, consuming sugar in moderate amounts is unlikely to significantly impact the microbes in your large intestine.

Sugar is essential for your body, particularly as a primary fuel source for your brain. It is naturally present in foods such as dairy, fruits, and vegetables, and also in free sugars found in processed foods like cakes, biscuits, flavoured yoghurts, and even in natural foods like honey. As with anything, moderation is crucial. Consuming more sugar than your small intestine can handle, which is approximately 7 teaspoons, can lead to sugar passing into the large intestine. There it can disrupt the balance of bacteria and create an environment that favours less helpful microbes [6].

Can my doctor help me to make an informed decision about the amount of sugar that I consume?

Yes, your doctor can help you make an informed decision about the amount of sugar you should be consuming. They can provide personalised advice based on your individual health, dietary habits, and existing medical conditions. Your doctor can help you understand the impacts of sugar on your health and guide you on how to moderate your intake effectively. They may also recommend seeing a dietitian or nutritionist for a more detailed plan.

Final Thoughts

While sugar is an essential part of our diet, its impact on gut health should not be overlooked. Excessive sugar intake can disrupt the balance of the gut microbiota, weaken the intestinal barrier and contribute to conditions like dysbiosis, leaky gut and chronic inflammation. These disruptions can lead to broader health issues, including metabolic problems such as insulin resistance and obesity. However, completely eliminating sugar from your diet is unnecessary, as it is vital for brain function and naturally present in many foods.

Vivere helps you take control of your health with personalised insights from state-of-the-art gut microbiome testing, nutritional guidance, science-backed supplements and expert support. Sign up today and start living better, for longer.

Sources

[1] What is Sugar? What is Sucrose? Is Sugar a Carb? | Sugar.org

[2] How Sugar Affects Gut Microbiota - MDPI Blog

[3] Sugar disrupts microbiome and immune function, leading to metabolic disorders - MNT

[4] Sugars and Gastrointestinal Health - PubMed

[5] High Intake of Sugar and the Balance between Pro- and Anti-Inflammatory Gut Bacteria - NLM

[6] Sugar And Its Relationship To The Gut: The Lowdown - The Gut Stuff

Author
Scott Weaver Medical Content Writer

Scott Weaver

Medical Content Writer

Scott is a professional content writer with more than four years of experience specialising in medical content. He always aims to produce clear, informative and reliable health and well-being-based content that readers can trust. He has covered a wide range of topics on a number of different medical conditions and treatments, both conventional and holistic. The aim of Scott’s work is to provide readers with the information they need to get a better understanding of their health and well-being. Outside of work, Scott enjoys cooking, travelling and watching sports – especially football, cricket and American football.
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Medical Reviewer
Yusra Serdaroglu Aydin - Head of Nutrition & Registered Dietitian at Vivere

Yusra Serdaroglu Aydin

Head of Nutrition and Registered Dietitian

Yusra is a registered dietitian with a multidisciplinary background in nutrition, food engineering, and culinary arts. She has a strong foundation in personalised nutrition, microbiome research, and food innovation. At Vivere, she leads the development and continuous improvement of nutrition-focused products and services. Her work involves aligning scientific research with product strategy, enhancing user experience, and supporting cross-functional collaboration. With experience in business development and training, she brings a practical, science-based approach to creating effective, health-oriented solutions.

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