Fridge or Shelf? How to Store Your Vivere NAD+ Pen

Does NAD+ need to be refrigerated? Yes, for long-term stability, your Vivere NAD+ pen and cartridges must be stored in the fridge between 2°C and 8°C. While the molecule is robust enough to survive shipping with a cold pack or a few hours at room temperature, constant heat will cause it to degrade (break down) over time into less effective ingredients like Nicotinamide. Always store your active pen in the fridge.

• The "Fridge Rule": Keep your pen and spare cartridges chilled (2–8°C) at all times.

• Don't Panic: Leaving it out overnight usually won't ruin it, but put it back immediately.

• The Colour Check: Fresh NAD+ is clear and can have a yellow tint. If it turns dark or cloudy, it may be degraded.

• Travel Smart: Use the Vivere cool bag for flights or long car journeys.

The simplest way to remember how to handle NAD+ is to think of it like fresh milk.

When you buy milk, you put it straight in the fridge.

• In the Fridge: It stays fresh and potent for months.

• On the Counter (1 hour): It is absolutely fine.

• On the Counter (2 days): It starts to "spoil" (lose potency).

NAD+ is a bioactive molecule. It wants to react with things.

Heat acts like a catalyst. It excites the molecule, causing it to break apart before it ever enters your body.

If left in a warm room (over 25°C) for too long, the NAD+ molecule undergoes oxidation and hydrolysis. It splits into two parts:

1. Nicotinamide (Vitamin B3).

2. ADP-Ribose.

While these aren't toxic, they aren't what you paid for. You want the full NAD+ molecule to fuel your body. The cold temperature "freezes" this reaction, keeping the molecule stable and ready for action.

A lot of people wonder whether leaving their NAD+ out overnight by accident has ruined it.

The Answer: Probably not.

Short "temperature excursions" (up to 24 hours at room temperature) are usually acceptable. The degradation process is slow, not instant [1].

• Action: Put it back in the fridge immediately.

• Result: The cartridge is still safe and effective to use.

However, if you left it in a hot car or on a radiator for a day, that is a different story. In that case, we recommend discarding the cartridge.

How do you know if your NAD+ has gone "bad"?

Fresh NAD+ is typically clear or has a slight yellow tint.

Degraded NAD+ often changes colour and becomes brownish.

• Dark: Sign of significant degradation.

• Cloudy/Particles: Do not use. This indicates contamination or separation.

You don't need to be housebound just because your medication needs a fridge.

When you fly or drive, you simply need to maintain the cold chain.

• Use the Cool Bag: Your Vivere Starter Kit comes with an insulated travel case.

• Ice Packs: Freeze the gel pack the night before.

• The Hotel Fridge: As soon as you arrive, transfer your pen from the bag to the hotel minibar.

Bioavailability isn't just about injections vs. pills. It is also about storage.

You have chosen the most potent form of NAD+ available. Don't let it go to waste by leaving it on the bathroom shelf. Make a habit of putting your pen back in the fridge immediately.

"Bioactive molecules like NAD+ are sensitive to environmental stressors. Just as we keep fresh, nutrient-dense food in the fridge to prevent spoilage, we must protect NAD+ from thermal degradation. Maintaining the cold chain is non-negotiable if we want to preserve the potency and integrity of the treatment."

Vivere helps you take control of your health with personalised insights from state-of-the-art gut microbiome testing, nutritional guidance, science-backed supplements, NAD injections and expert support. Sign up today and start living better, for longer.

[1] The stability of pyridine nucleotides - PubMed