Why NAD+ Might Give You Vivid Dreams (And Better Sleep)
Last Updated: 16 January 2026

Does NAD help you sleep? Yes, because NAD+ is a fuel that supports proteins that are important for your body's internal clock (Circadian Rhythm). It activates a specific protein called SIRT1, which tells your body when to be awake and when to sleep. Many users report having vivid, cinematic dreams when they first start therapy; this is actually a positive sign that your brain is finally entering deep REM sleep cycles after years of deprivation.
Key Takeaways
The Clock Fuel: Your internal body clock (Circadian Rhythm) stops working smoothly without NAD+.
SIRT1 is the Key: This protein regulates your sleep genes, but it only works when NAD+ is present.
Vivid Dreams = Repair: Intense dreams are a sign of "REM Rebound", your brain catching up on lost deep sleep.
Natural Melatonin: Boosting cellular energy helps your body produce its own sleep hormones naturally.

The Body Clock Connection (Circadian Rhythms)
We often think sleep happens just because we are tired. But actually, sleep is a tightly programmed schedule run by your Circadian Rhythm.
Your circadian rhythm tells cortisol to be released in the morning and melatonin/sleep to be released at night.
As we age, the circadian rhythm may not work as well. You could feel wired at 11pm but exhausted at 10am.
This happens because NAD+ participates in pathways that influence circadian proteins [1]. When your levels drop by age 40 or 50, the signal becomes weak. Restoring NAD+ gives your rhythm the boost it needs to work again.
"SIRT1": The Gene That Tells Time
Deep inside your cells, there is a "guardian" gene called SIRT1.
SIRT1 interacts directly with your body's "clock genes" (specifically one called PER2) [2]. It ensures that your metabolism slows down at night so you can rest.
However, SIRT1 is NAD-dependent. It cannot function properly without fuel.
Low NAD+: SIRT1 stays dormant. Your body doesn't get the strong signal to shut down.
High NAD+: SIRT1 is supported. It regulates your core body temperature and metabolic rate, preparing you for deep, restorative sleep.
The "Vivid Dream" Phenomenon
One of the reports from new Vivere NAD+ users is vivid dreaming. There is no need to worry and this is actually a good thing.
It is a phenomenon known as REM Rebound [3].
REM (Rapid Eye Movement) is the stage of sleep where you dream. It is also where your brain processes emotions and refreshes your memory.
If you have had low energy or poor sleep for years, you have likely been starved of REM sleep. Some users report more vivid dreams with NAD+ therapy, which could reflect changes in sleep patterns.
The vivid dreams may be a sign your brain is experiencing deeper sleep stages than before.
Deep Sleep vs. Light Sleep
Not all sleep is equal. You can sleep for 8 hours, but wake up exhausted if you stay in "Light Sleep."
Light Sleep: Good for resting the body, but doesn't fully recharge the brain.
Deep / REM Sleep: Crucial for cognitive function, mood regulation, and memory [4].
NAD+ supports the architecture of sleep, helping you transition smoothly from light dozing into the deep, restorative stages where true recovery happens.
Don't Fear the Dreams
If you start having movie-quality dreams, it means the therapy is working.
By fixing the fuel supply to your Circadian Rhythms, you are rebuilding the natural biological architecture of a good night's rest.
Nutritionist's Corner: Final Thoughts
"Sleep architecture is heavily influenced by our circadian rhythms, which are regulated by NAD-dependent proteins. The vivid dreams reported by many users are often a sign of REM rebound. NAD+ participates in cellular processes that help support deep, restorative sleep cycles, which are important for memory consolidation and emotional regulation."
Sources
[1] Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1 - PubMed
[2] SIRT1 regulates circadian clock gene expression through PER2 deacetylation - PubMed
[3] Rapid Eye Movement Sleep Behavior Disorder - StatPearls - NCBI Bookshelf
Author

Yusra Serdaroglu Aydin, MSc RD
Head of Nutrition and Registered Dietitian
Yusra is a registered dietitian with a multidisciplinary background in nutrition, food engineering, and culinary arts. During her education, her curio...