Ditch the Coffee: Using NAD+ for Executive Focus and Clarity

NAD+

Last Updated: 16 January 2026

What are the best supplements for focus and concentration? While caffeine is the most common choice, it only masks fatigue by blocking sleep signals in the brain [1]. NAD+ therapy is more reasonable for executive focus because it actually supportscellular energy (ATP) production within your neurons [2]. This provides steady, crash-free energy and enhanced mental stamina without the jitters, anxiety, or afternoon collapse associated with coffee.

Key Takeaways

  • Caffeine works by suppression, not supply: It blocks "tired" signals (Adenosine) but doesn't actually give you energy.

  • NAD+ is a real supporter to fuel: It powers the mitochondria in your brain cells to work harder and longer.

  • No "Jitters": Unlike stimulants, NAD+ doesn't spike your cortisol (stress hormone).

  • Sustained Focus: Experience deep concentration without the slump.

NAD+ injection kit by Vivere

The "Borrowed Energy" Trap

Caffeine blocks your brain's Adenosine receptors. Adenosine is the chemical that tells your brain it is tired.

The Car Dashboard Analogy: Imagine your car's "Low Fuel" light comes on.

  • Drinking Coffee is like putting a piece of black tape over the light. You can't see the warning anymore, but the tank is still empty.

  • Taking NAD+ is like actually pulling over and filling the tank.

The Cortisol Spike (Stress in a Cup)

When you drink a double espresso, your adrenal glands release a modest level of cortisol [3]. This is your "fight or flight" hormone. More coffee means high cortisol.

This is why you feel "wired." Your heart beats faster. Your hands might shake. You feel alert, but you also feel anxious.

NAD+ is different. It is not a stimulant. It does not trigger your adrenal glands. It simply provides the resources your brain needs to function calmly and efficiently.

Fueling Your Neurotransmitters

Your brain runs on chemicals called neurotransmitters (like serotonin and dopamine). These regulate your mood and focus.

Building these chemicals requires massive amounts of energy [4].

When your NAD+ levels are low, your brain struggles to produce them. This may leads to:

  • Brain fog

  • Irritability

  • Inability to focus on "Deep Work"

By restoring your NAD+, you may support the healthy production of these neurotransmitters. You don't just feel more awake. You feel more "locked in."

The "Crash-Free" Advantage

The problem with stimulants is the roller coaster.

  1. 9:00 AM: Coffee. Spike in energy.

  2. 11:00 AM: Jitters.

  3. 2:00 PM: The Crash. You feel like you need sugar or more coffee.

NAD+ provides steady-state energy.

Because Vivere uses subcutaneous injection, the molecule is released slowly into your system.

There is no spike. There is no crash. 

Upgrade Your Operating System

If you are a high performer, you care about optimisation.

Drinking five cups of coffee a day is a brute-force solution that damages your sleep and increases stress.

NAD+ therapy is a reliable alternative that operates through different mechanisms. It respects your biology rather than tricking it.

Nutritionist's Corner: Final Thoughts

"Caffeine is a stimulant that borrows energy from the future; NAD+ is a supporter to fuel that powers the present. For sustained executive function, we need to move away from spiking cortisol with stimulants and focus on supporting neuronal ATP production. This leads to a calm, resilient focus rather than the jittery 'fight or flight' state induced by excess coffee."

Yusra Serdaroglu Aydin, MSc RD

Sources

[1] Actions of caffeine in the brain with special reference to factors that contribute to its widespread use - PubMed

[2] Brain NAD Is Associated With ATP Energy Production and Membrane Phospholipid Turnover in Humans

[3] Caffeine Stimulation of Cortisol Secretion Across the Waking Hours in Relation to Caffeine Intake Levels - PMC

[4] NAD+ in Brain Aging and Neurodegenerative Disorders - PubMed

Author
Yusra Serdaroglu Aydin, MSc RD - Head of Nutrition & Registered Dietitian at Vivere

Yusra Serdaroglu Aydin, MSc RD

Head of Nutrition and Registered Dietitian

Yusra is a registered dietitian with a multidisciplinary background in nutrition, food engineering, and culinary arts. During her education, her curio...

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