Brain Fog and Hot Flushes: Can NAD+ Help During Menopause?

Can NAD+ help with menopause symptoms? Yes, boosting NAD+ levels can combat the "energy crash" caused by hormonal decline. As oestrogen levels drop, your mitochondria (cellular batteries) lose one of their protector, leading to fatigue, brain fog, and metabolic slowing [1]. Replenishing NAD+ provides support for your cells’ energy processes, helping them function optimally even as hormone levels change.

• The Oestrogen-Energy Link: Oestrogen protects your energy production. When it leaves, you need a backup plan.

• Banishing Brain Fog: NAD+ supports the metabolic pathways that help brain cells function efficiently during hormonal shifts.

• Metabolic Reset: It helps reactivate a slowing metabolism to manage weight gain.

• Thermal Regulation: Reducing cellular inflammation can help the body manage hot flushes better.

Many women describe menopause not just as "the end of periods," but as a sudden power outage.

You might feel fine one day, and the next, you are exhausted, foggy and overheating.

This happens because oestrogen is not just a sex hormone.It helps your cells use energy efficiently. When oestrogen levels drop during perimenopause, metabolism can slow. . 

NAD+ steps in to ensure your cells have the raw fuel they need to keep the lights on, even without oestrogen’s guidance.

We have all been there. You walk into the kitchen and completely forget why.

This is often dismissed as "baby brain" or "menopause brain," but it is actually an energy crisis [2].

Your brain consumes 20% of your body’s energy. When your mitochondrial function dips due to hormonal changes, your brain is the first to suffer. It rations energy, shutting down tasks like short-term memory or sharp focus.

By injecting NAD+, you are supporting brain metabolism.

Vivere users often report that the "mental mist" lifts within the first week. It is not about being smarter; it is about having the energy to access the intelligence you already have.

"I haven't changed my diet, but I'm gaining weight."

This is the most frustrating complaint of menopause.

As oestrogen declines, your metabolic rate drops. Your body becomes less efficient at burning glucose and starts storing it as fat, usually around the middle (visceral fat).

NAD+ activates a family of proteins called Sirtuins.

Sirtuins are often called "skinny genes" because they regulate metabolism [3]. They tell your body to burn fat for fuel rather than store it. Boosting your NAD+ levels won't replace the gym, but it turns the metabolic dial back up, making your diet and exercise efforts actually count again.

Hot flushes are your body’s thermostat breaking down. The medical term is vasomotor instability. Your brain thinks you are overheating and panics by dilating blood vessels.

This is often triggered by cellular stress and inflammation [4].

While NAD+ is not a hormone replacement (HRT), it is a potent anti-inflammatory. By calming the oxidative stress in your cells, you help stabilise the body's internal environment.

Society tells women that exhaustion and brain fog are just part of the package.

The science disagrees.

These symptoms involve multiple factors, including changes in hormones and cellular energy.While you cannot stop the drop in oestrogen, you can change how your cells react to it by supplementing NAD+.

"The metabolic shift during menopause is profound. As oestrogen declines, mitochondrial efficiency drops, leading to the classic 'brain fog' and fatigue. While NAD+ is not a hormone, it supports the metabolic pathways that struggle during this transition, offering a non-hormonal tool to help women regain cognitive clarity and energy stability."

[1] Menopause and cognitive impairment: A narrative review of current knowledge - PMC

[2] Perimenopause and emergence of an Alzheimer's bioenergetic phenotype in brain and periphery - PubMed

[3] NAD+ as a signaling molecule modulating metabolism - PMC

[4] Menopause as risk factor for oxidative stress - PubMed