Can You Take NAD with Mounjaro (and Other GLP-1 Weight Loss Treatments)?

Understanding how supplements and medications interact is essential for your health. In this article, insights are provided by Vivere’s Head of Nutrition, Yusra Serdaroglu Aydin, a registered dietitian with a background in nutrition, food engineering and culinary arts. Her approach is grounded in science and shaped by a strong understanding of personalised nutrition and the human microbiome.

This article explores how NAD+ therapy and GLP-1 weight loss medications, such as Mounjaro, may work together, what science says about their effects and whether combining them could support sustainable weight management.

Here are the five biggest takeaways from this article about NAD+ and whether you can use it with GLP-1 medications:

• NAD+ plays a key role in energy production, metabolism and cellular repair, which may indirectly support healthy weight management.

• GLP-1 medications like Mounjaro work by regulating appetite and improving blood sugar control, leading to weight loss.

• Early evidence suggests NAD+ supplementation may enhance mitochondrial function and fat metabolism, although more research is needed.

• Combining NAD+ therapy with GLP-1 treatment appears safe for most individuals when monitored by a healthcare professional.

• Sustainable weight loss still relies on optimising diet, regular activity, good sleep and long-term lifestyle changes.

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every cell of the human body. It plays a vital role in energy metabolism, DNA repair and overall cellular health. Without NAD+, our cells would struggle to convert food into energy or maintain proper function [1].

As we age, NAD+ levels naturally decline. This is linked with lower energy, slower metabolism and an increased risk of age-related conditions. Supporting NAD+ levels through supplementation may help maintain optimal energy production and promote healthy ageing [2].

Recent studies have explored NAD+ for its potential to improve metabolic health, enhance mitochondrial function and support recovery from stress and inflammation. Vivere’s NAD+ injection pen is designed to optimise cellular energy production, helping you feel revitalised and more balanced from within.

GLP-1 medicines (glucagon-like peptide-1 receptor agonists) are a class of medications originally developed to treat type 2 diabetes. They work by mimicking the natural hormone GLP-1, which regulates blood sugar levels and helps control appetite [3].

These medicines slow stomach emptying, promote feelings of fullness and reduce hunger. In recent years, they have gained attention for their effectiveness in weight loss, especially among people who are overweight or living with obesity.

GLP-1 medications are available by prescription in the UK and should only be used under medical supervision. 

Mounjaro (tirzepatide) is a medication within this group that activates both the GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors. This dual action helps regulate blood sugar and appetite more effectively than traditional GLP-1 drugs [4] [5].

In clinical trials, Mounjaro has significantly reduced body weight while also improving insulin sensitivity. It is typically used as part of a broader health plan that includes nutritional support, regular exercise and lifestyle changes.

NAD+ is not a weight loss drug. Its role in cellular energy production and fat metabolism may support the body’s ability to maintain a healthy weight. Some research suggests that restoring NAD+ levels can enhance mitochondrial function, improve insulin sensitivity and support metabolic processes that promote fat burning [6] [7].

NAD+ supplementation may also increase energy and improve overall vitality, potentially complementing the effects of GLP-1 medications. However, responses vary depending on the health, age and metabolism.

In obese people or people experiencing age-related metabolic decline, higher NAD+ levels have been linked with improved mitochondrial activity and better metabolic health.

Despite this, NAD+ should not be viewed as a weight loss solution. It is most effective when combined with a balanced diet (aided by Vivere’s personalised nutrition plan), physical activity and other healthy lifestyle measures.

There is no known harmful interaction between NAD+ therapy and GLP-1 medicines such as Mounjaro. Both work through different biological pathways, meaning they are unlikely to interfere with each other.

Some people using GLP-1 medications may add NAD+ therapy to their routines to help maintain energy, reduce fatigue or support metabolic health while their appetite and calorie intake are reduced.

If you are taking tirzepatide (Mounjaro), NAD+ supplementation can usually be used alongside it. However, as with all combined treatments, this should only be done under the guidance of a qualified healthcare professional.

While GLP-1 medications and NAD+ therapy may support metabolic health, sustainable weight loss ultimately depends on long-term lifestyle habits. These four methods can help you maintain results and improve overall well-being.

A nutrient-rich, whole-food diet helps stabilise blood sugar, support gut health and promote steady energy levels. Prioritising lean proteins, fibre, healthy fats, and unprocessed foods can make a significant difference to weight management.

According to Vivere’s experts, focusing on personalised nutrition using foods that support your metabolism, gut microbiome and energy balance can help you lose weight more effectively and sustain it over time [8] [9].

Regular physical activity is one of the most effective ways to boost metabolism and maintain lean body mass. Combining cardiovascular exercise with resistance training supports long-term weight management, particularly when used alongside GLP-1 medications [10].

Exercise also enhances mitochondrial efficiency, which works alongside NAD+ to improve energy production and reduce fatigue.

Limiting alcohol, processed sugar and refined carbohydrates can help regulate appetite and reduce inflammation. These changes not only support weight control but also contribute to better gut health and overall energy balance.

Reducing stress and avoiding late-night snacking can also enhance metabolic stability and hormone regulation, both of which are essential for maintaining a healthy weight.

Quality sleep is essential for appetite regulation and metabolic health. Studies show that inadequate sleep can disrupt hunger hormones, leading to increased cravings and slower metabolism. Consistent rest for both physical recovery and long-term weight control is vital [11].

It is important to remember that NAD+ is not a weight-loss drug and primarily supports cellular energy and repair. Combining NAD+ therapy with GLP-1 treatments, such as Mounjaro, may provide complementary benefits for energy metabolism and overall well-being during the weight loss journey. While GLP-1 medications help regulate appetite and blood sugar, NAD+ supports cellular function and vitality, potentially aiding in sustaining progress. The most effective weight loss strategy integrates professional guidance with lifestyle changes, balanced nutrition, and personalised support.

Vivere helps you take control of your health with personalised insights from state-of-the-art gut health testing, nutritional guidance, science-backed supplements, NAD+ injections and expert support. Sign up today and start living better, for longer.

[1] NAD+ Supplement​s - Vivere

[2] Beginner's Guide To NAD+ - Vivere

[3] GLP-1 medicines for weight loss and diabetes: what you need to know - GOV.UK

[4] What Is Mounjaro® for Adults with Type 2 Diabetes - Eli Lilly

[5] A Beginners Guide to Mounjaro for Weight Loss - UK Meds

[6] NAD+ metabolism and its roles in cellular processes during ageing - PMC

[7] Therapeutic potential of NAD-boosting molecules: the in vivo evidence - PMC

[8] Biohacking: Best Foods For Weight Loss - Vivere

[9] Biohacking Diet - Vivere

[10] Biohacking Exercise - Vivere

[11] Biohacking Sleep - Vivere